ACP Journal Club. Aspirin did not reduce recurrence after a first-ever, unprovoked venous thromboembolism.

Setting: 56 sites in 5 countries. Patients: 822 patients ≥ 18 years of age (median age 54 y, 54% men) who had a first-ever, unprovoked, symptomatic deep venous thrombosis (DVT) (popliteal vein or more proximal leg veins) or acute pulmonary embolism (PE); and completed 6 to 12 months of anticoagulant therapy with warfarin. Exclusion criteria included > 2 years since VTE; other indications or contraindications for aspirin, other antiplatelet therapy, or nonsteroidal antiinflammatory drugs; or need for continuing oral anticoagulant therapy.